This method excludes cells with a total read counts outside of a specified interval, cells having less than a certain number of expressed genes, and genes expressed in less than a given number of cells.
| lowread_thres | numeric value. Cells will be excluded if their total expression level is below this threshold. Default to -Inf. |
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| lowread_high | numeric value. Cells will be excluded if their total expression level is higher than this threshold. Default to Inf. |
| min_cells | integer value. Genes expressed in less than this value will be excluded. |
| min_genes | integer value. If a cell has a total number of expressed genes lower than this value, it is excluded. |
| verbose | a logical indicating whether to print the dataset dimension at each filtering step. Default to TRUE. |
| data_status | character string. Specifies whether the gene expression levels used for calculation are raw ("Raw"), normalized ("Normalized") or have been imputed ("Smoothed"). Default to "Raw". |